Network evolution hinges on history

Reconstructing History of Social Network Evolution Using Web Search Engines

We propose a simple web search engine based method for collecting approximated historical data of temporally changing social adaptive networks, which are rather difficult to obtain experimentally in conventional research methods. In the proposed method, a search query string is combined with additional keywords that specify inclusion/exclusion of specific years to limit the search results to a ...

Opening the pore hinges on proline.

absence of Hh ligand, Ptc restrains Smo activity ; binding of Hh to Ptc releases Smo, which then transmits the intracellular signal. The regulation of Smo activity therefore occupies a pivotal position in the cellular response to Hh. Previous work had identified small molecules that inhibit or activate Hh signaling by interacting with Smo 6–8. These include the antagonist cyclopamine as well as...

History effects on network growth

Growth dynamic of real networks because of emerging complexities is an open and interesting question. Indeed it is not realistic to ignore history impact on the current events. The mystery behind that complexity could be in the role of history in some how. To regard this point, the average effect of history has been included by a kernel function in differential equation of Barabási Albert (BA) ...

Flexible antibodies with nonprotein hinges

There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more flexible and extendible and are capable of two-handed binding. Native chemical ligation was carried out under mild, non-denaturing conditions t...

Elastica with Hinges